The increased growth rate generally slows during childhood. An unusually large placenta and long umbilical cord may also occur. ![]() Mothers of children with BWS may have pregnancy complications, including premature delivery and polyhydramnios, meaning excess amniotic fluid. Abdominal wall defects such as omphalocele, which causes the inside of the abdomen to protrude through the navel, are also present at birth and may require surgery before an infant leaves the hospital. The major features of BWS, macrosomia and macroglossia, are often present at birth. Children with BWS may also have hemihyperplasia, in which some parts of the body are larger on one side than on the other. The most common features of BWS include macrosomia (large body size), macroglossia (large tongue), abdominal wall defects, an increased risk for childhood tumors, kidney abnormalities, hypoglycemia (low blood sugar) in the newborn period, and unusual ear creases or pits. Beckwith-Wiedemann syndrome (BWS) is a growth regulation disorder.
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